SIDE EFFECTS Clinical Trials and Postmarketing Surveillance. The adverse reactions listed below reflect the experience from investigational studies of Accutane (isotretinoin) , and the postmarketing experience. Others speculated it was because the acne medication had come under scrutiny because of its side effects. Although Accutane is no longer around, isotretinoin is still sold as Absorica, Amnesteem, Claravis, and generic isotretinoin. Many of the side effects and adverse reactions seen in patients receiving Accutane are similar to those described in patients taking very high doses of vitamin A (dryness of the skin and mucous membranes, eg, of the lips, nasal passage, and eyes). What I can say is that the side-effects of Accutane are quite minor in most cases--just dry lips and perhaps a few aches. You needn't be scared of them. You really ought to discuss these issues more fully with your dermatologist. Good luck. Dr. Meilleure réponse: Side Effects of Accutane - for the Consumer Accutane All medicines may cause side effects, but many people have no, or minor, side effects. Side Effects. Dry lips and mouth, minor swelling of the eyelids or lips, crusty skin, nosebleeds, upset stomach, or thinning of hair may occur. If any of these effects persist or worsen, tell your. And if a lower dose of any drug usually reduces side effects, then that means there might be a way to reap the benefits of Accutane, the only known “cure” for acne, without any of the major. Vitamin A supplements: High doses Vitamin A supplements has many of the same side effects as Accutane. Taking both together may increase your chance of getting side effects. Taking both together may increase your chance of getting side effects. Accutane (isotretinoin) is a powerful medication that is approved for people with severe acne that is non-responsive to other treatments. It is the most effective medication on the market for acne, but also comes with a worrying list of side effects, some of which can be lifelong. Even though I experienced annoying side effects, my Accutane results were worth it. Caroline Praderio/INSIDER. My adult acne resisted every treatment I threw at it.