The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions. Aripiprazole (marketed as Abilify) Asenapine Maleate (marketed as Saphris) Clozapine (marketed as Clozaril) Iloperidone (marketed as Fanapt) Lurasidone (marketed as Latuda) Atypical and typical antipsychotic drugs are prescribed to treat mental health issues involving psychosis or delusions such as schizophrenia. Abilify (aripiprazole) is part of a class of psychotropic medications called atypical antipsychotics that work by altering the activity of various neurotransmitters—dopamine and serotonin in. Abilify (aripiprazole) received market approval from the U.S. Food and Drug Administration (FDA) in 2003 for use in the treatment of schizophrenia and bipolar disorder. Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. A Cochrane review found evidence in schizophrenia. Although the editors of BipolarNews.org have made every effort to report accurate information, much of the work referenced here is in abstract or pre-publication form, and may not have received proper review by the scientific community at this time. Most atypical antipsychotics were discovered recently; however, clozapine is often referred to as atypical antipsychotic even though it was discovered more than 60 years ago. Atypical antipsychotics are also known as second generation antipsychotics. Invega (paliperidone) is used to treat schizophrenia but is also the only oral atypical antipsychotic with a formal FDA indication to treat schizoaffective disorder. Invega may also cause restlessness, weight gain, and sedation. Overview. Abilify (aripiprazole) is an atypical antipsychotic medication that is commonly used to treat schizophrenia. Your doctor may prescribe this medicine for other conditions as well.