What Happens When You Mix Klonopin (Clonazepam) and Alcohol? Klonopin/Clonazepam and Alcohol can be a dangerous combination when mixed together. Abusing these drugs on their own have a lot of negative health effects, but combining the two substances can cause a host of new potential consequences. While Xanax worked great for my anxiety, my psychiatrist just put me on Klonopin. I'm on a mild dose (o.5 Mil), and to take 1 every 6 hours (as needed). i do think klonopin tends to mix well with Xanax. I would say take the Xanax first then wait till you start to lose your buzz then take the k-pin. I would say take the Xanax first then wait till you start to lose your buzz then take the k-pin. Xanax stays in your body for less time than Klonopin. If you start by taking Xanax alone, your physician may start the Klonopin to help you better control your anxiety and panic attacks. If it helps, your physician may recommend that you decrease the dosage of your Xanax and wean yourself off it. Am new to Bluelight and have a question that involves taking Klonopin and Xanax at the same time. I have slight-to-decent knowledge based on past experiences, and am aware of the effects of benzo's on people, mainly when they are taken for the high it produces. Xanax and Klonopin are the respective trade names for alprazolam and clonazepam, two medications that belong to the benzodiazepine class of drugs (nicknamed “benzos”). Loricass~ My dr recently ordered xanax for me. I am currently on 2mg of Klonopin at night. He told me when I start the xanax to stop the klonopin and he told me the same thing when he put me on Valium. Klonopin lasts longer than Xanax; however, Xanax has a shorter half-life and affects people more quickly than Klonopin does. People who abuse benzodiazepine tranquilizers desire the relaxed feeling they cause. Additionally, people who use Klonopin and Xanax together want to relieve tension. they are both benzodiazpenes usually prescribed for similar conditions associated with anxiety and sleep. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fowler on mixing xanax and klonopin: Mixture results in added sedation, depending on the dose. Consult your prescribing doctor.