Zoloft belongs to a group of selective serotonin reuptake inhibitors (SSRI) and is designed for oral administration. Zoloft treats depression and other similar medical conditions by altering the chemicals in the brain which cause panic, anxiety and obsessive-compulsive symptoms when getting out of balance. Eligible patients may save on their ZOLOFT® (sertraline HCl) prescription with the ZOLOFT® savings card. Zoloft (sertraline) is used to treat depression, obsessive-compulsive disorder and panic and anxiety disorders. Includes Zoloft side effects, interactions and indications. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Is it okay to take a whole prescrip. pill the first day,but then discontinue using it the next day. My doctor prescribed me 50 MG Zoloft for anxiety, and OCD.He said to start off by taking half a pill for the first week. Zoloft is an SSRI (selective serotonin reuptake inhibitors) antidepressant prescribed for the treatment of depression, obsessive compulsive disorder , panic disorder, posttraumatic stress disorder , social anxiety disorder, and premenstrual dysphoric disorder. Zoloft is available as a generic drug. Find Help. Search the Resource Directory for therapists, clinics, treatment programs, support groups, and organizations (such as affiliates and global partners) specializing in OCD and Related Disorders in your area. Zoloft is commonly used to treat depression, panic disorder, social anxiety disorder, and other conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). DOSAGE AND ADMINISTRATION Dosage In Patients With MDD, OCD, PD, PTSD, And SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below.