The manufacturers of Zoloft do not recommend drinking alcohol while on the medication. Zoloft and alcohol act upon similar chemicals in the brain, which means that Zoloft could intensify the effects of the alcohol. Zoloft is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Learn about Zoloft (Sertraline Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Studies on alcohol and Zoloft have shown little data. But this doesn’t mean that mixing the two substances is safe. In fact, the. recommends avoiding alcohol while you take Zoloft. Hi Everyone, I started 25mg of Zoloft 1 week ago. I actually felt calm and not depressed. Today I started crying and feeling so depressed. How long does Zoloft take to work? Zoloft (sertraline generic) is a prescription drug used to treat depression, obsessive-compulsive disorder, panic disorder, PTSD, social anxiety disorder, and PMDD. Common side effects are dizziness, insomnia, nervousness, and sleepiness. Drug interactions and pregnancy and breastfeeding safety information are included. How to use Zoloft. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using sertraline and each time you get a refill. Lexapro is prescribed to treat depression and generalized anxiety disorder. Zoloft is prescribed to treat depression, obsessive compulsive disorder, and several other mental health conditions. Because Zoloft leaves your body so quickly, stopping it too abruptly can cause discontinuation syndrome to develop. Among the symptoms that may be experienced are nausea, tremor, dizziness, muscle pains, weakness, insomnia, and anxiety. Zoloft is part of a class of drugs called selective serotonin reuptake inhibitors, or SSRIs for short. SSRIs act on a specific chemical within the brain known as serotonin.