Doctors give unbiased, trusted information on whether Acetaminophen can cause or treat Drowsiness: Dr. Marx on tylenol makes you sleepy: Not usually , if you take only acetaminophen, but sometimes this medicine come as part of other medications like tylenol 3 or 4 or vicodin, then will cause drowsiness. If you are looking for some biochemical explanation, I’d encourage you to stop looking unless you are a researcher etc. But in other cases: According to WebMD’s Do OTC Painkillers Alter Emotions, Reasoning? it seems like acetaminophen MIGHT make you “care less” - at least about negative stuff. I take 4 Tylenol Extra Strength Arthritis within 24 hours now over 2 weeks and I feel sleepy all the time. When you run out of sheep to count, remember these simple tips for better sleep. Before you know it, your sleep problems will be a thing of the past. I am on my second dose 6 hours later and I am still having throbbing stabbing pains and difficulty sleepy; which is why I am on this site. I chose Tylenol PM because its the go to for everyone I know. I who don't even take over the counter drugs or prescriptions am shocked that this is not working for me. Does tylenol 3 make you sleepy Pm tylenol makes me stay awake All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. I took my Zoloft (according to GP can make you sleepy) and I took 1 mg Ativan. I'm starting to yawn a little but still don't really feel too tired. Doctors give unbiased, trusted information on whether Acetaminophen can cause or treat Drowsiness: Dr. Barnhart on does acetaminophen make you sleepy: Not usually , if you take only acetaminophen, but sometimes this medicine come as part of other medications like tylenol 3 or 4 or vicodin, then will cause drowsiness. How to use Tylenol Extra Strength. Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or. Paracetamol relieves pain like body ache, tooth ache, headache and even pain during menstruation and also helps to bring body temperature to the normal level during fever.