As you probably know, Femara is not approved for ovulation induction, mostly because Novartis doesn't want to pay for the studies and take on the liability when the drug is already being used by lots of people off-label. Femara to Treat Infertility After Clomid Attempts Fail - Femara vs. Clomid. Clomid (brand name) or clomiphene citrate (generic name) is an oral medication that is often used for stimulating ovulation in women that do not ovulate on their own. Letrozole for Superovulation. Letrozole is an oral fertility medication. It can be used to induce ovulation in women who don’t ovulate, or to produce multiple eggs in women who already ovulate on their own. Today I am 8 weeks and have had a painfully swollen ovary since ovulation. I had an ultrasound 1.5 weeks ago and my RE did not seem too concerned but the pain has not gone away. Ovulation usually takes place about 36 hours after the shot. Some REs prefer to do the IUI at about 24 hours after, while others do it closer to 36 hours. As for the follicles, I would think about two of the eggs would have been mature by the time ovulation happened. Femara is also commonly used in cases of Clomid resistance when Clomid is unable to stimulate ovulation over at least three treatment cycles and despite increasing dosages. I've been charting my temperature too and it went up a little today, but not as much as usual after ovulation. If anyone out there has taken Femara or knows what to expect, I would really appreciate your thought and/or advice. Femara (letrozole) is used in the treatment of infertility for ovulation induction. Letrozole is a fertility medication that is used for women with PCOS.