Common Side Effects of Depo-Provera. You should tell your doctor if any of the following side effects are severe or don't go away: Weakness or fatigue Depo-Provera (medroxyprogesterone acetate) is a form of progesterone, a female hormone used as contraception to prevent pregnancy. Depo-Provera is also used to reduce pain cause by endometriosis, and to ease pain and symptoms in women with metastatic uterine or kidney cancer. Depo-Provera, a contraceptive injection that's given every three months, contains the hormone progestin to help protect from unintended pregnancy. Provera testimonial. Thanks to provera all the testimonial supporters and testimonial sponsors of provera Mike's Weather Page! Reducing the amount of oil released by oil glands in the skin, it helps the skin to renew itself more quickly). Explains the medication medroxyprogesterone (Provera, Cycrin, Depo-Provera, Deop-Sub Q Provera 104), a drug used used to treat abnormal uterine bleeding, contraception, and for treating endometrial or renal cancer. You girls have to discontinue Depo Provera at once and I highly recommend never putting any hormones into your bodies ever again. I have experienced a living nightmare from Depo Prover for the past three years. Depo Provera, an injectable contraceptive, is a very effective birth control method. Before starting Depo Provera, it's important that you're aware of common side effects, as well as the importance of receiving your Depo injections on time. What You Need to Know About Essure by Amie Newman August 23, 2017 Essure, a permanent form of birth control, is in the crossfire of controversy, as some users experience unexpected and sometimes devastating complications. Depo-Provera is more than 99 percent effective at preventing pregnancy when used correctly. Since the risk of pregnancy is so low, there is no need to take prenatal vitamins as a backup measure just in case pregnancy occurs. Depo-SubQ Provera 104 contains medroxyprogesterone acetate (MPA), a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration.