Levodopa-carbidopa (Sinemet, Sinemet CR, Parcopa) is a combination medication of levodopa and carbidopa prescribed for the treatment of Parkinson's disease. Side effects, dosing, drug interactions , and pregnancy safety should be reviewed prior to taking this medication. How to use Sinemet 10-100. Take this medication by mouth with or without food as directed by your doctor, usually 3 to 4 times a day. Taking this medication with food may help to decrease nausea. Do not change the dose or settings on your pump unless you are told to do so by your doctor. Be careful to make sure your PEG-J tube does not become kinked, knotted, or blocked as this will affect the amount of medication that you receive. Sinemet ® (carbidopa levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome. Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. Sinemet has two chemicals present in it: carbidopa and levodopa. Sinemet constitutes a combination of medicines used mainly to treat Parkinson’s disease symptoms or related symptoms, such as muscle stiffness, shakiness, difficulty in body movements. A new formulation of Sinemet with a controlled-release (CR) was approved by the FDA in 2014. Sinemet CR tablets contain either 50 mg of carbidopa and 200 mg of levodopa, or 25 mg of carbidopa and 100 mg of levodopa. Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. It is primarily used to manage the symptoms of Parkinson's disease but does not change the course of the disease. [1] Do not stop taking Sinemet (carbidopa and levodopa tablets) all of a sudden or lower your dose without talking to your doctor. Side effects may happen. Side effects may happen. Take even during sign-free periods. Sinemet is a mix of levodopa and another drug called carbidopa. Carbidopa makes the levodopa work better, so you can take less of it. That prevents many common side effects of levodopa, such as. Sinemet is not suitable for everyone and can cause bothersome and serious side effects. Common side effects include nausea, vomiting, and involuntary movements. Common side effects include nausea, vomiting, and involuntary movements.