WELLBUTRIN XL®, the only extended-release bupropion with more than 15 years of experience in Major Depressive Disorder (MDD) and more than 10 years of experience in Seasonal Affective Disorder (SAD). Find patient medical information for Wellbutrin XL Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Clinical studies on Wellbutrin XL and weight loss showed that up to 23 percent of people taking it lost weight. Although it is not entirely clear why this occurs, it is thought that other side effects of the medication (such as loss of appetite, nausea, and vomiting) may be factors. Wellbutrin XL is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Describes the medication bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL) an antidepressant drug used to manage depression, and also to help with smoking cessation. Article includes descriptions, uses, drug interactions, and side effects. DESCRIPTION. WELLBUTRIN XL® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Bupropion (bupropion XL, Wellbutrin XL, budeprion XL) is a moderately priced drug used to treat depression. This drug is slightly more popular than comparable drugs. When treating depression with Wellbutrin XL, you may be started with a dosage of 150 mg a day. Your healthcare provider may increase this after three days to 300 mg a day. Warning Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. Okay, I have been on Wellbutrin 300 xl (generic) for more than a month now. I am still a little jittery in the morning but not as bad. I get headaches every afternoon/evening and so I have to beat them to the punch with an Aleve at about 2:00 and even then I may still get the headache but just not as bad.