Wellbutrin is typically taken in tablet form three times a day. It is important that Wellbutrin doses are taken at least six hours apart to decrease the risk of having a seizure. It is also not recommended to take Wellbutrin close to bedtime because it can make sleep difficult. Regular and stable use is the most beneficial way to take medication. Wellbutrin (Bupropion) received an overall rating of 6 out of 10 stars from 1478 reviews. See what others have said about Wellbutrin (Bupropion), including the effectiveness, ease of use and side effects. Too much Wellbutrin can increase your chance of having a seizure. If you take too much Wellbutrin, or overdose, call your local emergency room or poison control center right away. Do not take any other medicines while taking Wellbutrin unless your healthcare provider has told you it is okay. If you are taking Wellbutrin for the treatment of major depressive disorder, it may take several weeks. Wellbutrin XL: 150 mg PO qDay; may increase to 300 mg qDay. Aplenzin (bupropion hydrobromide): 174 mg PO qDay initially (equivalent to 150 mg bupropion HCl); after 1 week, may increase to usual target dose of 348 mg/day (equivalent to 300 mg bupropion HCL) Dosing considerations (SAD) Initiate treatment in the autumn prior to onset of seasonal depressive symptoms and continue through the winter. Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and call your. Wellbutrin XL can cause seizure. The risk of seizure is dose-related. The dose should not exceed 300 mg once daily. Increase the dose gradually. Discontinue Wellbutrin XL and do not restart treatment if the patient experiences a seizure. The risk of seizures is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold. Consider these. Wellbutrin (bupropion) is what’s known as an atypical antidepressant. It works by modifying the levels of certain chemicals in your brain. It’s sold in tablet form and is commonly prescribed as a treatment for conditions such as depression and seasonal affective disorder. It’s also prescribed as a medication for smoking cessation. Research shows that Wellbutrin (bupropion) can reduce. You should not take Wellbutrin if you have an eating disorder, angle-closure glaucoma, or a seizure disorder. People with bipolar disorder may be at an increased risk of experiencing manic, mixed, or hypomanic episodes after taking Wellbutrin. While bupropion is sometimes prescribed off-label to treat depressive episodes, it is not approved for the treatment of bipolar depression. Warnings. You should not take Wellbutrin SR if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Do not use Wellbutrin SR within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue. What is Wellbutrin? In the United States, Wellbutrin (also known as Bupropion) is already the most prescribed antidepressant. Wellbutrin was synthesized in 1969 by an American laboratory, and it was introduced in the country in 1985. Its experience was brief because a year later it was withdrawn from the market due to a significant incidence of.