DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Wellbutrin is the brand name for bupropion, a prescription drug that's used to treat depression. It's also used to treat seasonal affective disorder (SAD), a type of depression that usually. Wellbutrin may affect the sex drive (also known as libido). In previous clinical studies documenting the side effects of Wellbutrin, a decreased sex drive occurred in up to 3.1 percent of people taking Wellbutrin. Although most people tolerate Wellbutrin well, there are some potential side effects of the medication. Common Wellbutrin side effects can include agitation, weight loss, and a dry mouth. Wouldn't call it viagra, however, wellbutrin seems to have the least sexual side effects.. and I've tried nearly every drug of its kind. Not only does it reinstate one's libido, but it also helps for quitting smoking. Sexual side effects are common with antidepressants in both men and women, but there are options to prevent or reduce such side effects. Note: This document contains side effect information about bupropion. Some of the dosage forms listed on this page may not apply to the brand name Wellbutrin. I am taking Wellbutrin and i wanted to know if it causes weight loss or gain. Also will it interact with my Lipo& B12 shots. please respond. Find a comprehensive guide to possible side effects including common and rare side effects when taking Wellbutrin (Bupropion Hcl) for healthcare professionals and consumers. The Happy, Sexy, Skinny, Pill? Wellbutrin, an antidepressant that can spur weight loss and boost libido, is on everyone's lips. Sari Botton reveals why she's on auto-refill.