Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. Wellbutrin may also be used for purposes not listed in this medication guide. Important information. You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medications, or sedatives. Wellbutrin (bupropion) interacts with alcohol in a negative way and may increase the risk of severe or uncommon negative effects such as hallucinations, paranoia, seizures, anxiety, delusions, mood and behavioral changes, panic attacks, depression, and suicidal thoughts. Avoid or limit the use of alcohol while under this mix. If you frequently take alcohol, it’s necessary to talk with your. Does Wellbutrin Cause Hair Loss? Alopecia on Bupropion. By. Nancy Schimelpfening. Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial process. Nancy Schimelpfening. Medically reviewed by. Medically. Wellbutrin is an antidepressant and it can help people stop smoking.; Some studies show that Wellbutrin might be useful in treating methamphetamine dependence. It does not usually lead to weight. Wellbutrin XL is an antidepressant used to treat major depressive disorder and seasonal affective disorder.The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Wellbutrin XL may also be used for purposes not listed in this medication guide. Wellbutrin and other antidepressant medications can be a vital tool for someone battling depression or anxiety. However, as with all drugs, Wellbutrin comes with certain side effects that can be dangerous if mixed with alcohol. There are many medications that interact negatively with alcohol, which is why so many drugs come with an explicit warning not to mix with alcohol. Wellbutrin (bupropion) isn't as likely to lower your libido as other antidepressants, but there are potential side effects you should be aware of.