We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Hegab on claritin and tylenol pm ok together: There should be no issues combining Mucinex with tylenol (acetaminophen) pm. In Claritin (Loratadine) I did it last night and woke up A LOT with kind of panic attacks. I guess the claratin was trying to wake me up and fighting with the tylenol pm. Very strange. They went. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Kanter on can you take tylenol with loratadine: No interaction noted btwn NyQuil and. Compare Claritin D vs. Tylenol PM, which is better for uses like: Allergy, Cough and Congestion. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Tylenol PM 3.7/5 over Claritin D 3.5/5 in overall satisfaction. Compare Loratadine vs. Tylenol PM, which is better for uses like: Allergy, Seasonal Allergies and Sneezing. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Loratadine 3.9/5 over Tylenol PM 3.7/5 in overall satisfaction. I took a 12 hour Claritin D about 3 hours ago, and I'll probably take a Tylenol PM in about a hour or so. Is this ok or will it make me sick? Yes, you can take Tylenol PM and Claritin at the same time. However, doctors warn that the biggest side effect would be dry mouth, but no other risky concerns. Claritin D is an antihistamine (loratadine) and decongestant (pseudoephedrine). Tylenol is an analgesic (acetaminophen). But you should be asking your pharmacist who can professionally advise and check there are no particular contraindication issues (i.e. with other medications). DearCustomer. Thank you for writing to JustAnswer with your question. These are 3 different medications - Claritin is loratadine, and Tylenol PM is acetaminophen and dipenhydramine.