Bactrim (sulfamethoxazole and trimethoprim) and Cipro (ciprofloxacin) are antibiotics used to treat bacterial infections. The drugs are in different drug classes. Bactrim is a combination of sulfamethoxazole, an anti-bacterial sulfonamide (a Compare Ciprofloxacin vs Sulfamethoxazole / Trimethoprim head-to-head for uses, ratings, cost, side effects, interactions and more. Ciprofloxacin rated 5.6/10 vs Sulfamethoxazole / Trimethoprim rated 5.4/10 in overall patient satisfaction. Cipro (ciprofloxacin) is a good, cheap antibiotic that treats many types of bacterial infections, but it interacts with some food and drugs. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Comparison between ciprofloxacin and trimethoprim-sulfamethoxazole in antibiotic prophylaxis for transrectal prostate biopsy Doğan Atılgan , Yusuf Gençten , Engin Kölükçü , Şahin Kılıç , Nihat Uluocak , Bekir Süha Parlaktaş , and Fikret Erdemir The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [23] [24] [25] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. Bactrim (sulfamethoxazole and trimethoprim) is a combination of two antibiotics (a sulfa drug and a folic acid inhibitor) and Cipro (ciprofloxacin) is a quinolone antibiotic. Compare Ciprofloxacin vs. trimethoprim, which is better for uses like: Infection, UTI and Bacterial Infection. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Ciprofloxacin 2.6/5 over trimethoprim 2.3/5 in overall satisfaction. Compare Cipro vs Sulfamethoxazole / Trimethoprim head-to-head for uses, ratings, cost, side effects, interactions and more. Cipro rated 5.8/10 vs Sulfamethoxazole / Trimethoprim rated 5.4/10 in overall patient satisfaction. Abstract. In a prospective, randomized, double-blind study, the effect of ciprofloxacin (250 mg orally, twice daily) was compared with that of trimethoprim-sulfamethoxazole (160 mg of trimethoprim and 800 mg of sulfamethoxazole orally, twice daily) on 45 patients with complicated urinary tract infections. Compare Cipro vs. Sulfamethoxazole-Trimethoprim, which is better for uses like: Infection, UTI and Bladder Infection. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews.