Severe respiratory depression and respiratory arrest may occur. Therapy with phenothiazines should be administered cautiously in patients who might be prone to acute alcohol intake. Therapy with phenothiazines should be administered cautiously in patients who might be prone to acute alcohol intake. Chlorpromazine can also potentiate the CNS depressant effects of drugs like barbiturates, benzodiazepines, opioids, lithium and anesthetics and hence increase the potential for adverse effects such as respiratory depression and sedation. Can Haldol cause Respiratory Depression? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Care should be taken to avoid increasing respiratory depression. If administration of a stimulant is desirable, amphetamine, dextroamphetamine or caffeine with sodium benzoate is recommended. Stimulants that may cause convulsions (e.g., picrotoxin or pentylenetetrazol) should be avoided. Because of its CNS depressant effect, Thorazine (chlorpromazine) should be used with caution in patients with chronic respiratory disorders such as severe asthma, emphysema and acute respiratory infections, particularly in children (1 to 12 years of age). Chlorpromazine (Thorazine, Largactil) is a phenothiazine used to treat emotional disorders such as schizophrenia, nausea, vomiting, severe pain, and continuous hiccups. It may also be used to treat other conditions as determined by your doctor. Pharmacology of Medications Used To Treat Opioid Addiction - Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs Your browsing activity is empty. Activity recording is turned off. Patients Receiving Chlorpromazine (Thorazine) Assessment Prior to administration: • Obtain complete health history, especially of mental illness, respiratory, gastrointestinal, genitourinary disorders, alcohol and illegal drug use. Include blood studies: electrolytes, CBC, BUN, creatinine, HCG levels if indicated, and drug screens (for use of illegal drugs.) • Obtain patient’s drug. WebMD provides information about interactions between Thorazine Rectal and agents-that-may-cause-respiratory-depression-sodium-oxybate. Sodium Oxybate/Agents that May Cause Respiratory Depression Interactions. This information is generalized and not intended as specific medical advice.