Professional guide for Allopurinol. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. Purinethol (mercaptopurine) is a potent drug. It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the responsible physician is experienced with the risks of Purinethol and knowledgeable in assessing response to chemotherapy. The most up to date, comprehensive, regulated information about medicines. Easy to use, trusted and recommended by healthcare professionals Predicting potential for toxicity to thiopurine drugs (6-mercaptopurine, 6-thioguanine, and azathioprine) Pediatric Drugs. Traitement chez l'adulte et l'enfant. - Traitement d'entretien des leucémies aiguës. La dose habituellement préconisée est en moyenne de 1 à 2,5 mg/kg/jour soit 20-30 mg/m² à 50-75 mg/m² de surface corporelle par jour. Elle peut atteindre dans certains cas 5 mg/kg/jour. have been reported in patients treated with Mercaptopurine is not effective for prophylaxis or treatment of central nervous system leukemia. Product Portfolio – Global. The Global Brands are specialist products with established credibility and strong brand equity amongst healthcare practitioners and patients. drugs known to cause photoallergic, photosensitive and phototoxic reactions * photoallergic reaction chlorothiazide enoxacin estrogens fenofibrate The therapeutic efficacy, bone marrow toxicity, and liver toxicity of(AZA) and 6-mercaptopurine (6-MP) may be related to their metabolites: 6-thioguanine (6-TG).