Tamoxifen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: Increased bone or tumor pain; Pain or reddening around the tumor site Harry Connick Jr.’s wife Jill Goodacre has been taking tamoxifen since her breast cancer surgery. Here are the facts on tamoxifen's side effects and Tamoxifen blocks the actions of estrogen and is used to treat and prevent some types of breast cancer. Learn about side effects, interactions and indications. Tamoxifen and anti-depressant use. Some types of anti-depressants called selective serotonin reuptake inhibitors (SSRIs) can interfere with the metabolism of tamoxifen (how tamoxifen works in the body). Whether these SSRIs may impact the effectiveness of tamoxifen is under study. Natural Remedies For Tamoxifen Withdrawal Side Effects. If you are in the process of weaning yourself off of tamoxifen (and there are many reasons why you might want to do so) and need help with the resulting withdrawal side effects, this article shares some tried and true natural remedies to help you out. Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the FDA to treat people diagnosed with both early-stage and advanced-stage hormone-receptor-positive breast cancer. Learn more about tamoxifen in pill form. Tamoxifen citrate tablets USP, a nonsteroidal antiestrogen, are for oral administration. Each film coated tablet contains Tamoxifen citrate15.2 mg or 30.4 mg equivalent to Tamoxifen 10 mg or 20 mg respectively. Tamoxifen is used to treat breast cancer that has spread to other parts of the body in men and women. It is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy.