· traitement d'entretien : la dose minimale efficace doit être utilisée ; selon la réponse individuelle, celle-ci peut varier entre 5 et 10 mg/kg/jour (ou 250 mg/m 2 /jour si la dose est exprimée en surface corporelle). A high dose, intravenous amiodarone regimen may represent an effective and safe strategy in the routine coronary care unit setting for treatment of atrial fibrillation or flutter. Amiodarone affects the rhythm of your heartbeats. It is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Abstract. Although amiodarone is an effective drug for the treatment of life-threatening ventricular arrhythmias, no standard oral loading dose protocol has been defined, and patients often undergo prolonged hospitalization for amiodarone loading. The dose of amiodarone administered is tailored to the individual and the dysrhythmia that is being treated. When administered orally, the bioavailability of amiodarone is quite variable. Absorption ranges from 22 to 95%, with better absorption when it is given with food. Detailed Amiodarone dosage information for adults. Includes dosages for Arrhythmias; plus renal, liver and dialysis adjustments. Amiodarone (Cordarone) is a complex antiarrhythmic agent with multiple electrophysiologic effects, unusual pharmacokinetics, and numerous potentially harmful drug interactions and adverse effects. Cordarone IV (amiodarone hydrochloride) Intravenous. This products label may have been revised after this insert was used in production. For further product information and current package insert, please visit or call our medical communications department toll-free at 1-800-934-5556. Amiodarone injection is contraindicated in patients with known hypersensitivity to any of the components of amiodarone injection, including iodine, or in patients with cardiogenic shock, marked sinus bradycardia, and second- or third-degree AV block unless a functioning pacemaker is available. Pairwise comparisons between standard and reduced dose groups will be done using a Chi-Square or Fisher’s exact test to compare incidence rate of any type of toxicity, ablation, or amiodarone.