La spironolactone est un composé organo-sulfuré de la classe des stéroïdes, antagoniste de la principale hormone minéralocorticoïde, l'aldostérone, par compétition de liaison sur le récepteur des minéralocorticoïdes. Spironolactone has caused tumors in laboratory animals. Talk to your doctor about the risks and benefits of using this medication for your condition. Learn about Aldactone (Spironolactone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Aldosterone has an important role in the pathophysiology of heart failure. 1-4 Aldosterone promotes the retention of sodium, the loss of magnesium and potassium, sympathetic activation. SPIRONOLACTONE is a diuretic. It helps you make more urine and to lose excess water from your body. This medicine is used to treat high blood pressure, and edema or swelling from heart, kidney, or liver disease. Spironolactone Oral Suspension. CaroSpir is not therapeutically equivalent to Aldactone tablets. For an equivalent dose, CaroSpir results in 15 to 37% higher serum concentration compared to Aldactone tablets. Mortality hazard ratios for some subgroups are shown in Figure 2. The favorable effect of Spironolactone on mortality appeared similar for both genders and all age groups except patients younger than 55. Spironolactone Directions: Spironolactone is a water pill (potassium-sparing diuretic) available by prescription that is used to treat edema, high blood pressure, potassium deficiency, and hyperaldosteronism. Spironolactone (Aldactone) is used for treating acne, hair loss, high blood pressure, heart failure, and a condition called primary hyperaldosteronism. WARNING. Spironolactone, an ingredient of ALDACTAZIDE, has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). ALDACTAZIDE should be used only in those conditions described under INDICATIONS AND USAGE.