Gengraf - Clinical Pharmacology. Cyclosporine is a potent immunosuppressive agent that in animals prolongs survival of allogeneic transplants involving skin, kidney, liver, heart, pancreas, bone marrow, small intestine, and lung. Cyclosporine in recommended dosages can cause nephrotoxicity. The risk of developing cyclosporine-induced nephrotoxicity increases with increasing doses of cyclosporine and duration of cyclosporine therapy. Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually used along with other medications to allow your new organ to function normally. 2 Warnings and precautions Important warning about the dose of Methotrexate Take Methotrexate only once a week for the treatment of rheumatic arthritis, psoriasis or psoriatic arthritis. Read about the side effects associated with various types of psoriasis medications, including prescription oral and topical drugs. Indikasjoner Aktiv revmatoid artritt hos voksne som ikke kan kontrolleres med antiinflammatoriske midler (NSAID), antimalariamidler, sulfasalazin, penicillamin eller gullpreparat, eller når det foreligger kontraindikasjoner for bruk av disse midlene. For Psoriasis Patients (See also BOXED WARNING above) Psoriasis patients previously treated with PUVA and to a lesser extent, methotrexate or other immunosuppressive agents, UVB, coal tar, or radiation therapy, are at an increased risk of developing skin malignancies when taking Cyclosporine Oral Solution USP MODIFIED. Treatment with systemics. Generally, women and men should avoid the use of systemic medications for psoriasis when trying to conceive. Systemic medications for psoriasis should also be avoided when nursing as the drugs can be secreted in breast milk. Learn how UpToDate can help you. Select the option that best describes you Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). Environmental, genetic, and immunologic factors appear to play a role.