Sporanox (itraconazole) and Lamisil (terbinafine) are both considered first-line oral agents for the treatment of fungal nail infections (onychomycosis) according to various medical guidelines. The accepted regimen for terbinafine, one of the most effective treatments for dermatophyte onychomycosis, is continuous administration of 250 mg/day over 16 weeks. Hence, a newer cost-effective regimen with a well-tolerated oral antifungal agent is desirable. Terbinafine's fungicidal action, combined with its improved pharmacokinetic properties, makes it an ideal drug for the purpose.[ 3 , 4 ] Terbinafine is an effective treatment for DSO when pulse-dosed for seven days every three months but not every four months, the authors write. The advantages we see in a pulsed-dose schedule of. The optimal terbinafine dosing regimen consisted of alternate 1‐week pulses, with most patients on this regimen (19/20 cases; 95%) achieving total cure. CONCLUSION: Favorable treatment outcome was gained from this terbinafine 1‐week pulse regimen and also better compliance compared with a standard daily regimen. Comparative efficacy of continuous and pulse dose terbinafine regimes in toenail dermatophytosis: A randomized double-blind trial Pravesh Yadav 1, Archana Singal 1, Deepika Pandhi 1, Shukla Das 2 It is also possible that the total dose of terbinafine may be more important than the dosing regimen. 54 Our study utilized a total dose of 10,500 mg (pulse), as compared with 21,000 mg (standard, continuous) within the first 3 months. Detailed dosage guidelines and administration information for Lamisil (terbinafine hydrochloride). Includes dose adjustments, warnings and precautions. Detailed Terbinafine dosage information for adults and children. Includes dosages for Onychomycosis - Toenail, Tinea Pedis, Tinea Corporis and more; plus renal, liver and dialysis adjustments. In conclusion, pulse terbinafine therapy is an effective regimen for the treatment of dermatophyte nail infections. Key words: onychomycosis, terbinafine, pulse.