Menopausal symptoms include mood swings, hot flashes, sleep disruption, changes in libido; Hormone replacement therapy is the only treatment that targets all of those symptoms Progesterone, sold under the brand name Prometrium, is used to treat overgrowth of the lining of the uterus. It's also prescribed to treat amenorrhea (a lack of menstrual periods) caused by stress. Progesterone is a hormone in both men and women. It plays a greater role for women, though, as it’s related to menopause, pregnancy, and overall health. Progesterone is a female hormone that prepares the lining of the uterus for a fertilized egg. The oral version of this medication is used for the prevention of endometrial hyperplasia in postmenopausal women receiving estrogen therapy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do not use any type of progesterone replacement, natural or synthetic, during pregnancy. Some patients may have an increased risk of blood clots, stroke, heart attack, or breast cancer, depending on their medical history. Side Effects. Nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness, or drowsiness may occur. Q: My wife is 50 years old and has been into menopause for the last two years. Since then she has been plagued with frequent uti's, 10 so far in the last twelve months. When you think of progesterone most of us are conditioned to think that it causes weight loss. But the truth is that progesterone can cause both weight loss and weight gain, depending on the situation of who is using it. I was on Prometrium for several years and switched to the generic Progesterone when it came available a couple months back. Now I'd totally swear by Prometrium cause it worked for me and as far as side affects go there were 2 and they weren't that bad and only lasted a couple hours after I took the pill so I took it at night and everything was.