Summary. Dry mouth is found among people who take Omeprazole, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Lyrica, and have High blood pressure. Omeprazole is in a class of drugs known as proton pump inhibitors that decrease stomach acid. Known as Prilosec in its over-the-counter form, omeprazole is prescribed for acid reflux disease, heartburn and stomach ulcers. A dry mouth is one of the rare side effects of Prilosec, occurring in less than 1 percent of people taking the medication. If you are taking Prilosec and dry mouth occurs, you can try to sip water often and avoid alcohol, tobacco, and caffeinated beverages, among other things. 1. Scand J Gastroenterol. 1995 Mar;30(3):216-8. Omeprazole and dry mouth. Teare JP(1), Spedding C, Whitehead MW, Greenfield SM, Challacombe SJ, Thompson RP. Medications new to the body can cause many side effects and the pharmacist should be able to tell you if this will go away and the amount of time it may take. Just wondered what the problem is that you are taking Prilosec as the problem may be worth a few side effects that may eventually subside. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. In clinical trials using either dual therapy with PRILOSEC and clarithromycin, or triple therapy with PRILOSEC, clarithromycin, and amoxicillin, no adverse reactions unique to these drug combinations were observed. Adverse reactions observed were limited to those previously reported with omeprazole, clarithromycin, or amoxicillin alone. Certain dentures and artificial tooth or filling of dental cavities too give a metallic taste (ruled out in your case). Sjogren’s syndrome (will cause dry mouth and not drooling of saliva) and copper or lead toxicity are other possibilities. There are things that can cause dry mouth besides meds. Like air conditioning, for one thing. Prilosec does cause dry mouth, but its a pretty rare reaction. I take Prilosec in the evenings and for awhile it really helped the dry mouth but now, not so much. I'm a mess of issues right now that I vented about in an earlier post but I just wanted to tell you that the dry mouth MUST have something to do with the gastro stuff because I'm suffering too. I'm suffering from a whole heck of a lot and I'm about ready to crack!.