Prednisone is a steroid people use to treat autoimmune disorders, but it can also affect how the body reacts to insulin. This can be a contributing factor to the development of diabetes. This. Prednisone is a drug that contains synthetic cortisol. When a person takes prednisone, the body stops making enough cortisol on its own. This can lead to withdrawal symptoms when the person stops. Prednisone (Sterapred) is a prescription corticosteroid, a man-made form of steroids that the body normally produces to fight illnesses and injuries. Prednisone alternating with cyclosporine has been recommended at doses of prednisone 1 mg/kg/day PO plus cyclosporine (10 mg/kg/day PO in 2 divided doses) based on actual or ideal body weight, whichever is lower. Amy Campbell, a registered dietitian and certified diabetes educator at Joslin Diabetes Center in Boston, explains that prednisone raises blood glucose by inducing insulin resistance, causing insulin, either that produced by your body or injected insulin, to become less effective. Prednisone Directions: Prednisone is a prescription corticosteroid used in dogs and cats to treat various conditions such as Addison's disease, inflammation from arthritis, allergies, and certain autoimmune diseases. 2. Upsides. Prednisone helps dampen down an over-reactive immune system and reduces inflammation. Can help control severe or incapacitating allergic conditions unresponsive to conventional treatment including asthma, allergic rhinitis, and atopic dermatitis. Brand names are Deltasone, Kedral, Medrol, Orasone, Prelone, Sterapred DS. Approved by the FDA in 1955, prednisone is the synthetic form of a hormone made by the human adrenal gland, called a steroid. Prednisone official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Most significantly, these types of side effects are reversible: it will disappear when the dosage is reduced or when the medicine is quit. Keep in mind that the advantageous (good) effect of prednisone simply cannot be divided from the beginning for a minimum of a few of these unwanted side effects.