Hi everyone. I have been on Paxil CR for aprox. 3-4 months and keep gaining weight. This is unacceptable for me as I have ALWAYS BEEN thin. I am weaning myself off and weaning into Wellbutrin that I had left over to avoid real bad withdrawal. Weight gain is also seen in people who take Paxil. In rare cases, some people may experience severe side effects of the drug which require immediate medical attention. However, more important thing related to Paxil is that it causes withdrawal symptoms when a person suddenly stops taking the drug. Moreover, a steadily growing body of scientific evidence suggests that increasing your daily exercise may affect not only weight loss, but also help your depression. paxil is great at first then you realize it's tricky side effects that no one tell you about. like no sex drive and you can't orgasm, you have no emotion anymore and you gain weight, especially when you try to come off paxil and end up going back on cause you can't take the withdrawal. Only thing Paxil ever did for my weight was help me gain it. After I stopped taking it (medically supervised) I lost 15 pounds in about 2 months without making any other lifestyle changes. After I stopped taking it (medically supervised) I lost 15 pounds in about 2 months without making any other lifestyle changes. Paxil ® (paroxetine hydrochloride) is a prescription medication used to treat several conditions of the brain. Several side effects are possible with Paxil, and weight loss appears to be one of them. Not usual side effec: This is not a usual side effect. However if there are other adverse reactions ( which are not common) such as diarrhea, nausea, hyponatremia and others , these could result in weight loss. Paxil (Paroxetine) is a drug that has been approved since 1992 for the treatment of major depression. It is considered by many to be a highly effective medication for various types of anxiety, specifically: generalized anxiety disorder, social phobia, OCD, and panic disorder. This website's purpose is to document Paxil (paroxetine) withdrawal symptoms along with offering advice in how to combat them. I can't speak for the birth control side of it, but I gained 80 pounds in the span of a year or so when I started Paxil. After getting off pills altogether, eating a very clean diet, and working out a few times a week, I lost all that weight in about seven months.