Using Nexium for a long period of time may increase the risk of inflammation of the stomach lining, according to the FDA. At least one study showed long term use of Nexium and other PPIs could also increase the risk of death. The FDA warns that patients should never take Nexium 24HR for more than 14 days at a time. Find patient medical information for Nexium oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Nexium (esomeprazole) is used to treat gastroesophageal reflux disease (), ulcers, certain bacteria in the stomach, and inflammation of the esophagus.It can also be used to prevent ulcers in patients taking medicines called NSAIDs. Esomeprazole is more popular than other proton pump inhibitors. It is available in brand and generic versions. Prescription esomeprazole comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth or to open, mix with water, and give through a feeding tube, and as packets of delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) granules for suspension. NEXIUM is a prescription PPI used in adults for healing and symptom relief of acid-related damage to the esophagus called erosive esophagitis (EE); to treat heartburn and other symptoms that happen with gastroesophageal reflux disease (GERD); to reduce the risk of stomach ulcers in some people taking pain medicines called non-steroidal anti-inflammatory drugs (NSAIDs); along with antibiotics. Nexium, or esomeprazole, is a proton pump inhibitor. It is used to treat gastroesophageal reflux disease, duodenal ulcer disease, and erosive esophagitis. See why Nexium 24HR is the 1 choice of doctors for treating frequent heartburn. Just one pill a day gives you 24-hour protection. Stop acid before it starts. Esomeprazole, sold under the brand name Nexium among others, is a medication which reduces stomach acid. It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth or injection into a vein. Common side effects include headache, constipation, dry mouth, and. Nexium should be taken at least one hour before a meal. Do not crush or chew a delayed-release capsule. However to make swallowing easier, you may open the capsule and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow right away without chewing. Do not save the mixture for later use. The capsule can be given through a nasogastric (NG) feeding tube. Read and carefully. You can also call the PfizerPro Customer Service Center at 1-800-505-4426 to place a request. To order Pfizer Vaccines, please visit or call 1-800-666-7248, Monday through Friday, 8:00 am to 8:00 pm Eastern Time. * Not all Pfizer products are available for sampling through this site.