Essential Phentermine Information. Whether you're new to the medication, or looking for more in-depth information, the following resources are a great place to start! MEDICATION GUIDE QSYMIA® (Kyoo sim ee’ uh) (phentermine and topiramate extended-release) Capsules CIV Read this Medication Guide before you start taking Qsymia and each time you Phentermine is an inexpensive drug used to decrease appetite. It is used with a reduced calorie diet and exercise to help you lose weight. It is more popular than comparable drugs. Since 2002, the Absolutely Thin® Online Medical Weight Loss Program has had proven results using weight loss medication & counseling. Let our nationwide team of doctors & practitioners help you achieve weight loss success. But when you look at real patient reviews you see something quite different: Most people do admit that Phentermine can help them lose weight (in the short-term) but almost everyone puts back on the weight that they lose once they stop the medication. Phentermine and topiramate come as extended-release capsules to take by mouth. The medication is usually taken with or without food once a day in the morning. Phentermine is a prescription weight-loss drug. Most doctors agree that phentermine works by suppressing the appetite and upregulating the metabolism, though the specific pathways are not fully understood. Phentermine is an appetite suppressant used together with diet and exercise to treat obesity. Learn about side effects, interactions and indications. How does Adipex work? Phentermine HCl – the main ingredient in Adipex – is a sympathomimetic amine, which means it stimulates the nervous system. More specifically, it promotes the release of norepinephrine, which is a neurotransmitter (chemical in the brain) that evokes a stress response such as the “fight or flight” reaction and it. How to use Phentermine HCL. Take this medication by mouth as directed by your doctor, usually once a day, 1 hour before breakfast or 1 to 2 hours after breakfast.