Summary. Heart palpitations is found among people who take Aleve, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Tylenol, and have Back pain. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Check with your doctor immediately if you notice any of these warning signs. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation for many medical conditions. It is the active ingredient in the over the counter medication Aleve. Cardiovascular side effects have included peripheral edema (3% to 9%) and palpitations (3%). Blood pressure may be elevated by naproxen (the active ingredient contained in Aleve) which may have clinical relevance in patients with comorbid illnesses. Yes, Aleve and other NSAIDs (Aspirin, Ibuprofen, and prescription-only meds like Toradol, and also the recent lawsuits against Vioxx) can cause heart palpitations, and you are taking a higher dose than is recommended (the pill insert says do not take more than 2 in 24 hours). Took one 500 Naproxen and within an hour had strong heart palpitations which were happening every few seconds. Took an Ativan.05mg to help calm them. Summary. Heart palpitations is found among people who take Naproxen, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Aspirin, and have Rheumatoid arthritis. “Commonly used painkillers including ibuprofen increase the risk of developing an irregular heart rhythm by up to 40 per cent”, reported The Daily Telegraph. Related questions; Ive been getting palpitations occasinally my chest heart my heart has strange sensations when i take Aleve (napro more Ive been getting palpitations occasinally my chest heart my heart has strange sensations when i take Aleve (naproxen) pain is going away can it be costo? However, the size of the study and the extent to which the probabilities of heart attack or stroke are elevated by the medications concerns ACSH’s Dr. Gilbert Ross. The seven NSAID drugs examined by the researchers included such everyday medications as ibuprofen (Advil) and naproxen (Aleve).