Ibuprofen is an medicine used to manage mild to moderate pain, fever, inflammation, menstrual cramps, and types of arthritis. Common side effects are drowsiness, nausea, diarrhea, constipation, and ringing in the ears. Ibuprofen is an NSAID, which can cause stomach ulcers in some people. It also interacts with many other drugs. Pictures of Motrin (Ibuprofen), drug imprint information, side effects for the patient. What other drugs will affect Motrin? Ask your doctor before using Motrin if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Vaughn's Summaries Medical Summaries Drugs for Pain: Compare Pain Killers. Painkiller Summary Chart by Vaughn Aubuchon With Infants’ MOTRIN ®, you can give your baby pain and fever relief that lasts for up to 8 hours. Find relief from muscle pains, minor arthritis pain, toothaches and headaches, and reduce fever with MOTRIN® IB, which contains ibuprofen. Be sure to post the number for the poison control center by your home phone. If you think your child has taken too much medicine, call the poison control center at 1-800-222-1222. Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Motrin (ibuprofen) is a nonsteroidal anti-inflammatory drug indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis, for relief of mild to moderate pain, and for treatment of primary dysmenorrhea. Prescription ibuprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints).