Which skin diseases respond to methotrexate? Methotrexate has been used in the treatment of moderate to severe psoriasis for many years. It is now used in suitable patients that have other extensive or troublesome skin conditions. Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens, and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate Injection official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Methotrexate lung disease is the specific etiological type of drug-induced lung disease. It can occur due to the administration of methotrexate which is an antimetabolite, which is given for various reasons but commonly to treat rheumatoid arthritis. Academia.edu is a platform for academics to share research papers. INTRODUCTION. Methotrexate is an analogue of the vitamin folic acid; it inhibits cellular proliferation by inducing an acute intracellular deficiency of certain folate coenzymes. This impairs the intracellular trafficking of single carbon groups and results in impaired synthesis of thymidine, deoxyribonucleic acid (DNA), and ribonucleic acid. Methotrexate has been reported to cause fetal death and/or congenital anomalies. Therefore, Rasuvo is not recommended for females of childbearing potential unless there is clear medical evidence that the benefits can be expected to outweigh the considered risks. Treatment for radiation pneumonitis depends on how severe the condition is. For most people, symptoms clear up on their own within 7 to 10 days of appearing. Antineoplastic agent and immunosuppressant; folic acid antagonist. a 262 265. Uses for Methotrexate Breast Cancer. Treatment (alone or, more commonly, in combination chemotherapy) of breast cancer. a 262 265.