Compare Clonazepam vs. Melatonin, which is better for uses like: Insomnia. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Clonazepam 4/5 over Melatonin 3.6/5 in overall satisfaction. REM sleep behavior disorder (RBD) is a parasomnia associated with dream enactment often involving violent or potentially injurious behaviors during REM sleep that is strongly associated with synucleinopathy neurodegeneration. Clonazepam has long been suggested as the first-line treatment option for yes. providing you do not have any other co-morbidites and that the dosage of klonopin (clonazepam) is not too high to where it will cause severe. Summary. Drug interactions are reported among people who take Melatonin and Clonazepam together. This study is created by eHealthMe based on reports of 1,064 people who take Melatonin and Clonazepam from FDA, and is updated regularly. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Elliott on melatonin and klonopin mixing: It is a safe combination. I can think of a number of clinical scenarios where this would be very appropriate and I have quite a few patients on this combination. Taking melatonin along with sedative medications might cause too much sleepiness. br / Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal. Melatonin appears to be beneficial for the management of RBD with reductions in clinical behavioral outcomes and decrease in muscle tonicity during REM sleep. Melatonin also has a favorable safety and tolerability profile over clonazepam with limited potential for drug-drug interactions, an important consideration especially in elderly individuals with RBD receiving polypharmacy. Prospective. Learn about drug interactions between clonazepam oral and melatonin oral and use the RxList drug interaction checker to check drug combinations. Melatonin is active at ~ 250ug, and most supplements are in the milligrams nowadays. Since the supplements provide you with more than the body usually even produces for the sleep cycle, one of the pills you got (no matter the mg) would work for an amazing, refreshing sleep. As long as you're not operating heavy machinery or driving, etc!!! I take Clonazepam, appx. 2 mg/ day total and have taken it with Melatonin (up to 10 mg.) at bedtime with no problems.