Hi, I recently started mirtazapine and have had a good initial reaction to the drug – my energy is better, my mood. The one rather major problem is it seems to trigger or exacerbate my RLS. ROCHESTER, Minn. ― Here are highlights from the April issue of Mayo Clinic Health Letter. You may cite this publication as often as you wish. Overview; Mayo Clinic College of Medicine and Science; Mayo Clinic Graduate School of Biomedical Sciences; Mayo Clinic Alix School of Medicine; Mayo Clinic School of Continuous Professional Development Uses: Mirtazapine is prescribed for Depression and Insomnia and is mostly mentioned together with these indications. In addition, our data suggest that it is taken for Anxiety, although it is not approved for this condition*. Effects of Tapering off Antidepressants Vary from Person to Person. September 16, 2011. Dear Mayo Clinic: I have been on different medications for depression for years and would like to begin tapering off. Proper Use. Drug information provided by: IBM Micromedex. Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. Hi.I'm new to this website & to depression. I've recently been prescribed mirtazapine & I've looked into the side effects which include RLS.not only do I suffer that but it also affects my arms. I'm usually still awake into the early hours & it's driving me mad. Does this lessen the longer you take the drug? I'm finding myself drinking at. Mirtazapine is an antidepressant. The way this medication works is still not fully understood. It is thought to positively affect communication between nerve cells in the central nervous system and/or restore chemical balance in the brain. - Mayo Clinic – Appointments at Mayo Clinic Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Request Appointment. Treatment-resistant depression - Mayo Clinic – Treatment-resistant depression. Sometimes depression doesn't get better, even with treatment. Explore what… title = Pilot evaluation of mirtazapine for the treatment of hot flashes , abstract = This prospective, single-arm, pilot clinical trial, developed to evaluate the efficacy and tolerability of mirtazapine for alleviating hot flashes, was conducted between May 2001 and January 2002.