Many people compare Lexapro vs Zoloft. Both of these medications are selective serotonin reuptake inhibitors, commonly referred to as SSRI’s. Lexapro (escitalopram) and Zoloft (sertraline) are medications of the selective-serotonin reuptake inhibitor classification utilized most commonly for the management of major depressive disorder (MDD). Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems. Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines. Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines. Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems. Lexapro (escitalopram) is good for treating depression and anxiety. It is. Lexapro vs Zoloft comparison. When it comes to prescription antidepressants, patients often try different drugs before settling on one that works best for them. Lexapro and Zoloft are both prescription SSRI antidepressants prescribed to treat depression and anxiety. They work by resto. Zoloft is commonly used to treat depression, panic disorder, social anxiety disorder, and other conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Lexapro is prescribed to treat depression and generalized anxiety disorder. Zoloft is prescribed to treat depression, obsessive compulsive disorder, and several other mental health conditions. Zoloft vs Lexapro: The Battle of The SSRIs Anxiety and depression can be anything from a nuisance to a life altering problem. Most symptoms can disrupt relationships, work, and one’s ability to accomplish daily tasks. Zoloft (sertraline) and Lexapro (escitalopram) are antidepressant drugs in the selective serotonin reuptake inhibitor (SSRI) class used for treating depression, and anxiety disorders. Compare Lexapro vs Zoloft head-to-head for uses, ratings, cost, side effects, interactions and more. Lexapro rated 7.7/10 vs Zoloft rated 7.4/10 in overall patient satisfaction.