Detailed Diltiazem dosage information for adults. Includes dosages for Hypertension, Congestive Heart Failure, Atrial Fibrillation and more; plus renal, liver and dialysis adjustments. Cardizem is a calcium ion inhibitor. The side effects of this druginclude rash, swelling in the hands and feet, trouble breathing,slow heartbeat, and upper stomach pain. If necessary, your healthcare provider may increase your dose to control your blood pressure, or decrease your dose if you experience bothersome diltiazem side effects. Short-Acting Diltiazem Dosing Short-acting diltiazem ( Cardizem ® ) is only approved for treating angina (not high blood pressure ). As the dose of diltiazem hydrochloride extended-release capsules (once-a-day dosage) is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area-under-the-curve of 2.7 times. When the dose is increased from 240 mg to 360 mg, there is an increase in the area-under-thecurve of 1.6 times. The oral lethal dose in mice, 50% range from 415 to 740milligrams per kilogram while that of humans is not known. This is because of extensive metabolism. The blood levels usually vary once the recommended dose of Cardizem is administered, this in turn limits blood levels usefulness in overdose cases. In several cases it has been documented 1 g to 18g where patients expressed the following. Calcium channel blocker (CCB) toxicity is one of the most lethal prescription drug overdoses; therefore, understanding the emergent management of such cases is essential. Overdoses of immediate-release CCBs are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest. Background: This case report highlights serious cardiovascular adverse effects with a conventional dose of trazodone as a result of its potential interaction with omeprazole. As the use and risk of abuse of diltiazem increases, these reports serve to highlight the possible hazards and to alert physicians to what must be regarded as a dangerous and potentially lethal drug in overdosage. Some symptoms of a diltiazem overdose may include fluid retention, fainting, and difficulty breathing. If the overdose was recent, a healthcare provider may administer certain medications or pump the stomach. Treatment may also involve supportive care, which consists of treating the symptoms that occur as a result of the overdose.