Lamotrigine may be an effective treatment for depression, although results have been inconsistent. In this exploratory pilot study we analyzed data from a five-month, uncontrolled, open-label trial to determine if participants scoring higher on a measure of pretreatment irritability were more responsive to lamotrigine. Furthermore, aggression and irritability as measured by the Overt Aggression Scale (OAS) significantly declined over the 8-week titration period, and this gain was maintained through the last 6 weeks of lamotrigine monotherapy. In addition to treating depression, lamotrigine reduces irritability in patients with depression [5], bipolar disorder [6], and borderline per- sonality disorder [6,7]. Can Lamictal cause Irritability? Irritability is a known side effect of Lamictal. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Irritability is a known side effect of Lamictal. Summary. Irritability is found among people who take Lamotrigine, especially for people who are female, 40-49 old , have been taking the drug for 1 - 6 months, also take medication Lamictal, and have Depression. Aggressive or violent behavior usually happens due to epileptic discharges or their postictal changes. Certain antiepileptic drugs like lamotrigine, Keppra can also cause irritability and aggression as a side effect.You need to inform the treating neurologist about this. The study is based on lamotrigine (the active ingredients of Lamictal) and Lamictal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Synonyms of Irritability are also considered in the study. Some psychiatric side effects of Lamotrigine that are rare include mania, irritability, emotional upheaval, depression, confusion, confusion, concentration issues, anxiety, and agitation. Lamotrigine induced mania is usually treated with Topiramate or lithium. Lamotrigine extended-release (long-acting) tablets are used with other medications to treat certain types of seizures in patients who have epilepsy.