Using Klonopin alone could take a few hundred thousand milligrams to overdose and die because of it. Still, the how danger of Klonopin overdose is when the drug is mixed with other depressant much such as much. Additionally, Klonopin stays in the system longer than other benzodiazepines like Xanax. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Klonopin Clonazepam is a fast-acting benzodiazepine. It relaxes the mind by anxiety calming neurotransmitters. Klonopin prevents muscle spasms, reduces anxious feelings and causes sleepiness. Xanax Alprazolam is also a fast-acting benzodiazepine. Klonopin affects neurotransmitters the same way Klonopin does. Hello BigBakerMan. Yes, it can be. Clonazepam non generic Klonopin is a long acting benzodiazepine. It has a very long half life meaning it takes your body, a longer time to get rid of the drug, than say a Xanax might, which is a short lasting Benzodiazepine. Klonopin clonazepam has a very high LD50, or the expected lethal dose for 50 percent of test subjects. Because this amount is so large, there how to get ativan no conversions for human equivalency. Using Klonopin alone could take a few hundred thousand milligrams to overdose and die because of it. Klonopin overdose symptoms can actually onset much sooner — at essentially any amount higher than a prescribed dosage amount. Klonopin Overdose Symptoms The severity of Klonopin overdose symptoms are dependent on the level of intoxication. The maximum daily dose of Klonopin prescribed to an adult for any condition is 20 milligrams, notes Drugs.com. Any amount in excess of 20 milligrams in a day is an overdose and can be fatal, especially if a person is on any other drug. Identifying Overdose. Klonopin slows communication in the central nervous systems. It can slow important mental and physical functions to dangerously low levels. Signs and Symptoms of Clonazepam Overdose. Clonazepam is a commonly abused drug, due in part to the desirable effects it produces (relaxation, euphoria, sedation) and how easy it is to access due to the fact that is widely prescribed. Factors Influencing Overdose and Lethal Dose Between 1999 and 2015, overdose deaths involving a benzodiazepine drug like Valium jumped sevenfold, per the Chicago Tribune. Benzodiazepine overdose rates are on the rise, and most fatalities include another drug or alcohol as well.