Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Feola on can i take benadryl and claritin together: Taking Loratadine in the morning and Diphenhydramine at night will help you avoid the drowsiness side effects of Diphenhydramine and help you if the Loratadine is not controlling your symptoms for the full 24 hours. Did you mean if it was okay to take loratadine with Benadryl? Yes, it's fine to take Claritin (loratadine) and Benadryl (diphenhydramine) together. Main question is why you would want to take the two together. Diphenhydramine/benadryl is generall more potent in terms of desired effect, so adding Claritin is unlikely to confer much benefit, and it may worsen peripheral side effects like dry mouth and visual changes. We are here to help and to share experiences. Both of those medications are antihistamines so I would not recommend you to take it at the same time. diphenhydramine-phenylephrine oral will increase the level or effect of loratadine oral by affecting hepatic enzyme CYP2D6 metabolism. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health Can patients take Benadryl and Claritin together If there are no heart, blood pressure, urinary or kidney contraindications this combination will not likely be a problem. These antihistamines are generally safe medicines. Using cetirizine together with diphenhydramine may increase side effects such as dizziness, drowsiness, and difficulty concentrating. According to the web site drugs, diphenhydramine is on list of. They are both in the same family (antihistamines), but a few people have daytime symptoms so take non-sedating med (like loratadine) and its effect wears off before next day's dose, so take a sedating (/older) antihistamine (like benadryl) at bedtime for continued relief and to aid with sleep. Like cetirizine (zyrtec) or loratadine (claritin), instead of benadryl antihistamines like chlor trimeton and are safe for pregnant women to take (as the less sedating claritin zyrtec). Taking.