Bactrim is a common drug and is available at the pharmacy counter with a prescription from a licensed health care professional. The price varies from pharmacy to pharmacy and depends largely on health insurance coverage. What's eHealthMe? eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. Bactrim, which is a sulfa-based antibiotic, contains the active ingredients sulfamethoxazole and trimethoprim, according to Drugs.com. In addition to acne treatment, physicians prescribe the medication to treat certain types of pneumonia, bronchitis and ear infections. My dermatologist prescribed Bactrim for moderate acne. I had taken Bactrim a year and a half ago for a couple of months and Bactrim cleared up my skin and it stayed that way until recently. Bactrim is not an antibiotic that I typically prescribe for Acne as it is a rather big gun antibiotic for serious infections. As it can be very effective for acne, Bactrim has significant side effects such as causing a life threatening rash. However, in severe acne cases I may prescribe it for 1-2 weeks for quick control of severe cystic acne prior to initiating another treatment regimen. Sulfamethoxazole-trimethoprim is one of the most effective antibiotics used to treat acne. It is a combination of two drugs in a fixed ratio. Sulfamethoxazole-trimethoprim treats only the red, pus-filled pimples of acne and acne cysts (nodules) deep under the skin. User Reviews for Bactrim to treat Acne. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. What's eHealthMe? eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. (Bactrim) is a very effective treatment for acne that it should not be given to patients who are allergic to sulfur. Reviews and ratings for bactrim when used in the treatment of acne. 68 reviews submitted. Bactrim tends to be the most effective oral antibiotic, so it would be wise to give that a try. Bactrim is a great antibiotic and clears up most people's acne in a couple of weeks. Most bactrim doses last for 1-2 months.