Step 4 - Obagi Nu-Derm Blend Fx: Use this product in the evening mixed with your tretinoin/Retin-A. Measure ½ to 1 gram (approximately 1 to 2 pea-size drops) and apply evenly to the entire face. Obagi Tretinoin Cream: Product Overview and Information. The Obagi Tretinoin Cream is a skin care solution used to treat aging skin problems such as fine lines and wrinkles, discoloration of the skin, and rough, dry skin that can occur with aging and the environment. Obagi Blender is a topical skin lotion designed to be used in tandem with tretinoin cream. Applied to the skin nightly, Obagi Blender lightens uneven patches of skin, such as age spots and freckles. This treatment is also designed to correct skin at the cellular level by stimulating the production of collagen and. Should I use the Blender or Obagi clear? Well, here is what I recommend: In most cases just using the Obagi blender is sufficient UNLESS you have mature skin and you have significant sun damage, photo damage, aged skin or sun spots. Can I use obagi nu derm and retin a together? I have been on retin a.025 for about 9 months and recently just bumped up to retin a.05. I just use citaphil cleanser, but I want to buy the obagi nu derm system. Use Obagi Tretinoin Gel with caution if allergic to fish. Not available in select states including MA, MT, NH, NY, and TX, due to state regulations regarding the ability of physicians to dispense prescription drug products in their offices. Tretinoin, generic for Retin-A, is actually retinoic acid, the same acid the body creates from dietary Vitamin A to keep the skin youthful, firm, plump, wrinkle-free and clear of blemishes and acne. Use the “Clear” product. “Clear” is the brand name of the step 3 product, which contains prescription-strength hydroquinone. “Clear” is designed to help correct the various discolourations on your skin to leave you with a more even skin tone. † Study results for a 24-week evaluation of the efficacy and tolerability of twice-daily use of the Obagi Nu-Derm Normal to Oily System with 0.025% tretinoin cream, N=20 ‡ Study results for a 24-week evaluation of the efficacy and tolerability of twice-daily use of the Obagi Nu-Derm Normal to Oily System with 1.0% retinol, N=33 This Obagi retinol review will walk you through all of the benefits of retinol including how to use this vitamin to dramatically improve your skin.