For example, if you take a substance like Percocet, the half-life refers to how long it takes for the concentration of the substance in your body to decrease by half. Understanding Percocet half-life is relevant for a few different reasons. Opioid painkillers are unique, because anyone can become dependent on these drugs. Percocet addiction can impact people who have no personal or family history of addiction. This drug does not discriminate and can affect anyone. close What To Expect. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Your call is confidential, and there's no pressure to commit to treatment until you're ready. Opiates are never meant to be a long-term treatment plan to alleviate pain because if you take them continuously, your body will become dependent and you’ll become addicted. When you reach the stage where you cannot stop taking opiates, even if you want to, that’s when addiction has set in. This causes the brain to become dependent on Percocet. When there is no more Percocet in its system, it will start to react via withdrawal symptoms. When there is no more Percocet in its system, it will start to react via withdrawal symptoms. How Long Does It Take to Become Addicted to Percocet? Thousands of Americans develop a painkiller addiction every year. There are a number of factors that can impact how long it will take for a Percocet addiction to develop. Does anyone know if I'll be physically dependent by the time the bottle is over? I'm using 5-10 mg a day. Either one 5mg dosage or a double dose. Once a day. I'm using 5-10 mg a day. Either one 5mg dosage or a double dose. How long does it take to recover from oxycodone addiction of 12 years? Is it okay to take oxycodone with cocaine? How long does it take to become addicted to norco? A person becomes dependent on opiates when he feels unable to function normally without the drug. The length of time it takes to become dependent can vary from person to person. While medication-assisted treatment (MAT) may appear to take a frustratingly long time, it works to wean the person off physical dependence on large doses of opioids like Percocet. Working with a doctor’s oversight during detox, whether it involves replacement medications or not, helps to manage symptoms so they do not become too uncomfortable.