Along with its needed effects, clomiphene (the active ingredient contained in Clomid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Clomid treatment has some potential for adverse effects. Side effects are definite cons of clomiphene use. Adverse effects are seen in some, but not all women using the drug. Side effects are definite cons of clomiphene use. Clomid's side effects aren't so bad, as far as fertility drugs are concerned. The most common side effects are hot flashes, breast tenderness, mood swings, and nausea. The most common side effects are hot flashes, breast tenderness, mood swings, and nausea. What is Clomid and how does it work? Clomid is an oral medication that can be used to stimulate ovulation. It works by blocking estrogen receptors at the hypothalamus, which is an important hormonal control center for the body. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. clomid side effects Side effects of Clomiphene are imperceptible, and do not pose a direct threat to the female body. In the most frequent cases there are abdominal pain, insomnia and weight gain. How Does Clomid Work for Fertility? Medically reviewed by University of Illinois-Chicago. There are relatively few side effects and it’s generally well-tolerated by women who take it. Risks. Whether or not this is the case, make sure to understand the potential side effects and work hand-in-hand with your doctor to follow the prescribed treatment protocol. This way you'll see the safest and likely the best results. Clomid side effects can even be fairly mild and generally disappear once Clomid is stopped. With higher doses of this fertility drug, Clomid side effects are more pronounced. About 10 percent of women that take Clomid report Clomid side effects such as: The side effects of Clomid are typically reversible if you stop taking the drug. If you experience any of the side effects listed above while taking Clomid, you should stop taking Clomid and.