Along with its needed effects, loperamide (the active ingredient contained in Imodium) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It may take up to 48 hours of taking Imodium A-D before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment. hi maddie. i take one or two imodium chewable tablets per day and it doesnt appear to make me feel sick at all.maybe you're feeling fatigue, shaky , and weak because you've been having D for so long now? i know that used to knock me out. i dont think the imodium would make the D happen - in fact, i think if you took too much you'd probably get. it does make me a little sick to my stomach for a couple of hours then I get to feeling better. I think my doctor told me once that you can get prescription immodium that wont cause that. that has been way back and my memory isnt the best but you could ask your doctor about it and see. Uses: Imodium is prescribed for Diarrhea and IBS and is mostly mentioned together with these indications. In addition, our data suggest that some patients take it for Withdrawal Symptoms, although this is not an approved use*. Why am I feeling slightly sick after taking probiotics? I just started taking probiotics a few days ago and feel slightly sick. Is there anything I can take to reduce the side effects? this is my second week of 4 tykerb and 2nd day of 2 xeloda and i'm feeling so sick to my stomach. diarrhea and nausea. taking imodium and kytril and pepto but although they help still having. stomach just keeps churning and groaning and gurgling. i wish i could be like so many others who are taking these pills without much in the way of se's. I had been taking 8 imodium a day for quite a long time while I had the ostomy, but a few days ago, I stopped taking it completely. I didn't feel like it was doing me any good. It never crossed my mind it might not be safe to do so. Once it enters your body, it makes its home in your GI tract, where it begins to multiply and make you feel sick. Your body senses the infection and wants it out of there—which is where things. Keep an eye on your diet (write a food diary if you’re still trying to identify trigger foods) and consider taking steps to reduce your stress level if you feel that it may be the trigger for your diarrhea.