Reports of probable carcinogens found in generic sartans are causing concern in hypertension and heart failure practice, and raising larger questions about the safety of the drug supply. Table 1: Drug Interactions Associated with Increased Risk of Myopathy/Rhabdomyolysis; Interacting Agents: Prescribing Recommendations * For patients with HoFH who have been taking 80 mg simvastatin chronically (e.g., for 12 months or more) without evidence of muscle toxicity, do not exceed 10/40 mg Vytorin when taking lomitapide. MedWatch alerts provide timely new safety information on human drugs, medical devices, vaccines and other biologics, dietary supplements, and cosmetics. This information has been updated in the December 15, 2011, FDA Drug Safety Communication: Revised dose limitation for Zocor (simvastatin) when taken with amiodarone. Zocor is the brand name of simvastatin, a prescription drug used to lower blood cholesterol. Zocor belongs to a class of drugs known as statins, also called HMG-CoA reductase inhibitors. This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. VYTORIN® (ezetimibe and simvastatin) Tablets. DESCRIPTION. VYTORIN contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, an HMG-CoA reductase inhibitor. INTRODUCTION. Lipid altering agents encompass several classes of drugs that include hydroxymethylglutaryl (HMG) CoA reductase inhibitors or statins, fibric acid derivatives, bile acid sequestrants, cholesterol absorption inhibitors, and nicotinic acid. For the treatment of hypercholesterolemia, including hyperlipidemia, hyperlipoproteinemia, or hypertriglyceridemia, as an adjunct to dietary control; and for reduction in cardiovascular mortality, including myocardial infarction prophylaxis and stroke prophylaxis. The following FDA safety notices may be specifically about Crestor or relate to a group or class of drugs which include Crestor (rosuvastatin). These notices may include a list of possible medication recalls, market withdrawals, alerts and warnings.