Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. DESCRIPTION. WELLBUTRIN XL® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses. It combines low doses of bupropion and naltrexone. Contains Nonbinding Recommendations Draft Guidance on Bupropion Hydrochloride This draft guidance, once finalized, will represent the Food and Drug Administration's (FDA's) Summary of Use during Lactation. Limited information indicates that maternal bupropion doses of up to 300 mg daily produce low levels in breastmilk and would not be expected to cause any adverse effects in breastfed infants. Bupropion is an antidepressant medication that affects chemicals within the brain that nerves use to send messages to each other. These chemical messengers are called neurotransmitters. Bupropion is a prescription drug. It comes in the form of an immediate-release tablet or an extended-release tablet. Both forms are taken by mouth. Warnings/Precautions. Major psychiatric warnings (use in treating psychiatric disorders): • Suicidal thinking/behavior (use in treating psychiatric disorders): [US Boxed Warning]: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. DESCRIPTION. CONTRAVE extended-release tablets contain naltrexone hydrochloride and bupropion hydrochloride. Naltrexone hydrochloride, USP, an opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. Bupropion comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth. The regular tablet (Wellbutrin) is usually taken three times a day, with doses at least 6 hours apart, or four times a day, with doses at least 4 hours apart.