250 mg PO twice daily is suggested by previous guidelines although dosing is not well established. A macrolide, such as erythromycin, is recommended for secondary prevention of rheumatic fever in patients allergic to both penicillin and sulfisoxazole; however, dosing recommendations are not provided in recent guidelines. Erythromycin Ophthalmic Ointment (Ilotycin) nursing considerations cleanse the infant's eyes as needed before application. Hold the tube in a horizontal rather than a vertical position to prevent injury to the eye from sudden movement. Prophylaxis for neonatal eye infection: Ribbon of ointment approximately 0.5–1 cm long is placed into lower conjunctival sac of neonate shortly after birth. Use a new tube of erythromycin for each neonate. Oral preparations of the different erythromycin salts differ in pharmacokinetics: 400 mg erythromycin ethylsuccinate produces the same free erythromycin serum levels as 250 mg of erythromycin base, stearate, or estolate. Erythromycin Ophthalmic Ointment belongs to the macrolide group of antibiotics. It is basic and readily forms a salt when combined with an acid. How to use Erythromycin Ointment. To apply eye ointment, wash your hands first. To avoid contamination, be careful not to touch the tip of the tube or let it touch your eye, eyelid, or any other. ILOTYCIN (erythromycin) Ointment. DESCRIPTION. ILOTYCIN™ Erythromycin Ophthalmic Ointment belongs to the macrolide group of antibiotics. It is basic and readily forms a salt when combined with an acid. fect of erythromycin andqrisk of adverse GI reactions.qlevels and riskoftoxicity from alfentanil , alprazolam , bromocriptine , carbamazepine , cyclosporine , cilostazol diazepam disopyramide , ergot alkaloids , felodipine , methyl- Erythromycin Ophthalmic Ointment - FDA prescribing information Erythromycin Ophthalmic Ointment official prescribing information for Caution should be exercised when erythromycin is administered to a nursing woman. Erythromycin ophthalmic preparations are used to treat infections of the eye. They also may be used to prevent certain eye infections of newborn babies, such as neonatal conjunctivitis and ophthalmia neonatorum. They may be used with other medicines for some eye infections.