Side Effects. See also Warning section. Hot flashes, nausea, leg cramps, muscle aches, hair thinning, headache, and numb/tingling skin may occur. A loss of sexual ability/interest may occur in men. Applies to tamoxifen: oral solution, oral tablet. Along with its needed effects, tamoxifen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Tamoxifen is used for the treatment of invasive breast cancer in men and women, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Side effects of tamoxifen. Find out about the side effects of the hormone therapy tamoxifen. Tell your doctor or nurse if you have any side effects so they can help you manage them. Skin rash Side effects of tamoxifen versus side effects of aromatase inhibitors Although both aromatase inhibitors and tamoxifen can cause menopausal symptoms such as hot flashes, many of their side effects differ. Can Tamoxifen cause Skin Problems? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Skin Conditions Sleep. Despite its protective effects against cancer, some women stop taking tamoxifen because of side effects like hot flashes, mood swings, nausea, vomiting, or weight gain or. One of the adverse effects of tamoxifen include hot flashes and vaginal dryness (reviewed in Neven and Vergotta 2001), but there have been no studies to determine effects on skin thickness, collagen content, elastic fibers or the formation of wrinkles.