doxylamine succinate oral and ibuprofen-oxycodone oral both increase sedation. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for Easy-to-read patient leaflet for Doxylamine. Includes indications, proper use, special instructions, precautions, and possible side effects. Includes indications, proper use, special instructions, precautions, and possible side effects. Do you mean, can i take doxylamine & advil ( ibuprofen ) together? Yes, there is no listed drug interaction between the two. Are you taking any other medications or supplements ? They may interact with one or both of the two you asked about. I've worked in pharmacy for awhile. There is no know interaction between the too. However to be on the safe side do not take anymore than 25mg of Doxylamine Succinate and take a regular does of. The study is based on ibuprofen and doxylamine succinate (the active ingredients of Advil and Doxylamine succinate, respectively), and Advil and Doxylamine succinate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. How to use Doxylamine Succinate Tablet. Read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. Summary. Drug interactions are reported among people who take Ibuprofen and Doxylamine succinate together. This study is created by eHealthMe based on reports of 28 people who take Ibuprofen and Doxylamine succinate from FDA, and is updated regularly. doxylamine succinate oral , hydrocodone-ibuprofen oral. Either increases toxicity of the other by pharmacodynamic synergism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment Interaction between Advil PM and Doxylamine Succinate: There is no known interaction between Advil PM and Doxylamine Succinate in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Interaction between Doxylamine Succinate and Ibuprofen: There is no known interaction between Doxylamine Succinate and Ibuprofen in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice.