Does the weight loss happen when you jump from 150 - 300? Or should I expect anything. Or should I expect anything. So frustrated, working so hard to pay attention to what I'm doing (eating) and exercising. Does Wellbutrin Help with Weight Loss? Just because a medication may help with weight loss doesn't mean it actually does a good job. When we talk about weight loss medications we always need to be asking the following questions: Even though you may experience weight loss on Wellbutrin, this medication is not specifically designed for losing weight. If you are interested in taking a weight loss pill, talk to your healthcare provider about taking a medication for weight loss. So true, wellbrutrin or bruproprion, zyban or whatever does NOT cause any weight gain. It is a stimulant and causes the opposite weight loss. I refuse to take any other anti-depressant. Hair loss is not limited to Wellbutrin, and other antidepressants may cause hair loss as well. When Does the Hair Loss Occur? Hair loss related to antidepressant medications is commonly noted around six months after starting or changing a medication. A: Wellbutrin (bupropion) immediate-release formulation may cause weight loss of about five pounds in 28 percent of patients. The sustained-release formulation may cause weight loss in about 15. How to lose weight with:Metformin, Naltrexone or Contrave - how they work, safety, risks - Duration: 9:54. Ford Brewer MD MPH 18,225 views I was on Citalopram 40mg for 2 years and gained a total of 40 lbs. My doctor switched me to wellbutrin xl 150 mg but I saw no difference in my weight so she just upped my dose to 300mg. Doc prescribed me 75 mg a day for depression and for a week and then next week I'm starting 150 mg a day. Will this cause weight loss and/or loss of appetite? Why Does Wellbutrin SR Cause Weight Loss? It is not entirely clear why Wellbutrin SR can cause weight loss. Wellbutrin SR can often cause a loss of appetite, nausea, and vomiting -- all of which may contribute to weight loss.