Does Prednisone cause Elevated Liver Enzymes? Last Update September 23, 2018 In 199 posts found by Treato discussing Prednisone and Elevated Liver Enzymes, no patients reported Prednisone causing Elevated Liver Enzymes. Although I have never drank any alcohol, my doctor says I have a fatty liver, and I wonder if that could be the cause of the pain. I also wonder about the small intestine. Have you ever heard of anyone having side pain when taking prednisone? I heard that if you have certain types of cancers, and you take Prednisone, it makes the cancer grow more rapidly. Is this true? Precautions. Before taking prednisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause. Prednisone is considered risky for expectant mothers to use, since it may cause harm to a developing fetus. Let your doctor know if you're pregnant, or may become pregnant, before taking prednisone. Alcoholic and nonalcoholic comprise the two main types of fatty liver. This differentiation between alcoholic and nonalcoholic is rather appropriate, since alcohol is a major cause of fatty liver and other causes are less frequent. Uses of Prednisone for Dogs Prednisone is an artificial corticosteroid that is commonly used when steroids are needed in dogs. Prednisone is an immune system suppressive drug that can also reduce swelling and pain. Corticosteroids can cause hypernatremia, hypokalemia, and fluid retention. These mineralocorticoid effects are most significant with fludrocortisone, followed by hydrocortisone and cortisone, then by prednisone and prednisolone. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. I was talking with a friend I hadn't spoken with for a while. She told me she was taking prednisone , a bell went off in my head, when my pain issues began over 15-17 yrs ago the Dr gave me shots of cortisone in knees and elbows. Prednisone is a synthetic corticosteroid that reduces inflammation and suppresses the immune system. Prednisone is prescribed for a wide range of conditions, especially autoimmune diseases.